Poloxamer 188/ Poloxamer 407/ Polyethylene Polypropylene Glycol CAS 9003-11-6 CAS NO.9003-11-6

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Poloxamer 188/ Poloxamer 407/ Polyethylene Polypropylene Glycol CAS 9003-11-6

Description:
Poloxamer, also known as Pluronic, is a nonionic triblock copolymer composed of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) units. It is a clear, viscous liquid or solid at room temperature, depending on its specific grade. Poloxamers are designated with a number, such as Poloxamer 188 or Poloxamer 407, which indicates their molecular weight and composition.

Specification:
The specifications of Poloxamer can vary depending on the specific grade and application. Here are some general specifications:

• Chemical formula: Variable, depending on the specific Poloxamer grade
• Molecular weight: Varies depending on the Poloxamer type, typically ranging from 2,000 to 14,000 g/mol
• Appearance: Clear, colorless or slightly yellowish liquid or solid
• Purity: Typically, not less than 99% or higher (depending on the grade)
• Hydroxyl value: Varies depending on the specific Poloxamer grade
• pH: Generally neutral (around 6-8)

Application:
Poloxamer has various applications in different industries, including:

1. Pharmaceutical and medical: Poloxamer is widely used in pharmaceutical formulations and medical applications. It is employed as a solubilizer, emulsifier, and stabilizer in liquid and semi-solid dosage forms such as creams, ointments, gels, and suppositories. Poloxamers can improve drug solubility, enhance bioavailability, and provide controlled drug release. They are also utilized in eye drops, nasal sprays, and other topical formulations.

2. Personal care and cosmetics: Poloxamer is utilized in the personal care and cosmetic industry. It is commonly found in skincare products, cleansers, shampoos, and conditioners. Poloxamers act as emulsifiers, surfactants, and texture modifiers, providing stability, foam enhancement, and improved sensory properties.

3. Industrial applications: Poloxamer has industrial applications as well. It is used as a lubricant and dispersant in various industrial processes, including plastics manufacturing, rubber production, and metalworking. Poloxamers can improve flow properties, reduce friction, and aid in dispersion of particles.

Features:

1. Nonionic nature: Poloxamer is a nonionic copolymer, meaning it does not carry an electrical charge. This property makes it compatible with a wide range of ingredients and formulations, as it does not interact strongly with pH or ionic conditions.

2. Thermal reversible gelation: Some Poloxamers exhibit a unique property known as thermal reversible gelation. They can form gels at lower temperatures and revert to a liquid state upon heating. This feature is useful in pharmaceutical formulations and can provide controlled drug release.

3. Solubilizing and emulsifying capabilities: Poloxamers have the ability to solubilize hydrophobic substances and stabilize emulsions. They can help improve the solubility and bioavailability of poorly soluble drugs and enhance the stability of oil-in-water or water-in-oil emulsions.

4. Biocompatibility: Poloxamers are generally considered biocompatible and well-tolerated by the body, making them suitable for pharmaceutical and medical applications. They are commonly used in ophthalmic and intravenous formulations.

 

Details

Product Name	Poloxamer 188	Appearance	White Powder
Form	Powder	Shelf Life	2 Years
Grade	Cosmetic Grade	Brand	Zorui
CAS	9003-11-6	Specification	99%

Poloxamer 188 Supplied is a synthetic block copolymer of ethylene oxide and propylene oxide. This kind of surfactant were firstly developed by America. They have almost no toxicity, little irritation on the skin and the mucosa. They are widely used as emulsifier, solubilizing agent, hydrophilic substrate of ointments and suppositories, artificial blood,artificial tear and artifical skin etc.At the same time it has the following functions:

 

1. Poloxamer can strengthen stamina, vigour and physical strength.

2. Poloxamer can improve the reactive sensitivity.

3. Poloxamer can improve the stress strength.

4. Poloxamer can promote function of sex hormone, ease the pain of muscle.

5. Poloxamer can improve the function of cardiac muscle.

 

ANALYSIS	SPECIFICATION	RESULTS
Appearance	White powder	Complies
Odor	Characteristic	Complies
Tasted	Characteristic	Complies
Assay	99%	Complies
Sieve Analysis	100% pass 80 mesh	Complies
Loss on Drying	5% Max.	1.02%
Sulphated Ash	5% Max.	1.3%
Extract Solvent	Ethanol & Water	Complies
Heavy Metal	5ppm Max	Complies
As	2ppm Max	Complies
Residual Solvents	0.05% Max.	Negative
Microbiology
Total Plate Count	1000/g Max	Complies
Yeast & Mold	100/g Max	Complies
E.Coli	Negative	Complies
Salmonella	Negative	Complies

 

Packaging	1kg-15kg packing	2 PE bag inside + 1 foil bag outside in carton
	25kg-50kg packing	2 PE bag inside + 1 foil bag outside in drum
	Other packing	Customized packing
Drum Size	D38cm*H60cm or customized, 25 kg/ drum
Shipping	1-50kg	International Express	Fast and convenient	Door to Door
	50-500kg	Air Transportation	Fast and cheap	To Air Port
	Above 500kg	Sea Transportation	Cheap and convenient	To Port

 

 

 

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